Protein S Proteins

Protein Information

Protein S is a vitamin K-dependent, potent neutral anticoagulant plasma glycoprotein. Protein S has a molecular weight of approximately 70 kDa and consists of a single polypeptide chain. The concentration of protein S in human plasma is 25 µg/mL, with a half-life of approximately two days. About 40% of Protein S in plasma is in a free form, whereas 60% is complexed with C4b-binding Protein (C4BP). Only the free Protein S functions as a cofactor to antigen presenting cells (APC) in the APC-dependent degradation of Factor Va and Factor VIIIa.

Synonyms

AW214361; Preproprotein S; PROS; PROS 1; PROS1; protein S; protein S (alpha); Protein S alpha; protein Sa; proteinS; PS 21; PS 22; PS 23; PS 24; PS 25; PS 26; PS21; PS22; PS23; PS24; PS25; PS26; PSA; rabbit protein S; THPH5; THPH6; unnamed protein product; vitamin K-dependent plasma protein S; vitamin K-dependent protein S; vitamin K-dependent protein S precursor